5th Annual WML Academic Symposium

Poster Presentation
Time: 4:00-5:30
Presenter: Saikrishna Bompelliwar
Title: Molecular Level Comparison and Stabilization of Promethazine Hydrochloride Complexes
Developed under the guidance of Dr. Rahul Haware, Pharmaceutical Sciences

Promethazine hydrochloride (PM-HCl) has a bitter taste and a crystalline nature. Eudragit® EPO and magna sweet MM 100 will be added to the PM-HCl to mask the bitter taste and improve the dissolution. As per previous studies, the formed complexes might be in amorphous nature. Therefore, an increase in active drug dissolution can be achieved. Previous studies state that the ratio of 1:10 (PM-HCl: Eudragit® EPO) would be sufficient to mask the bitter taste. The optimization of drug: polymer ratio of MM 100 will be carried out. The purpose of this research will be to understand the taste-masking mechanism of two materials to mask the bitter taste of PM-HCl and to check the stability of formed complexes.